My site (and many others) use Wordpress (the downloadable version, not the online account type).
The install is very simple, the hardest part is setting up the database - which itself isn't a large task.
From there, I create the webdesign as usual in XHTML and CSS, then copy and paste in segments of the code into the relevant WP files. Wordpress has multiple PHP files that are called from the main index file, so for example you put your <head> tags and head content in the header.php file and so on.
Have an experiment with it and you should soon get the idea of how it all pulls together.
Drupal can also be a good choice, out of the box there is the option of customising the site with the features you require, which includes the blog function amongst others.
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